Pain is subjective. It is a sensory and emotional experience that can be influenced by countless factors, ranging from expectations to mood or even faith. Chronic pain can be highly despairing and significantly affect one’s quality of life and emotional state. The currently available analgesic treatments don’t always work, and pain researchers keep searching for more effective options for pain management.
In the last decades, there have been many studies proposing that mindfulness meditation can reduce pain and improve health, both in experimental and in clinical contexts.
Mindfulness meditation is a cognitive practice that involves paying full attention to whatever internal and external experiences are occurring in the present moment, as you experience them. It is a technique that combines focused attention on breathing with objective non-judgmental acceptance of arising thoughts and sensations. This means accepting an experience with an even mind, not judging it as good or bad.
One of the main doubts regarding the analgesic effect of mindfulness meditation has been how exactly it happens. It could be argued that mindfulness meditation could simply reduce pain through a placebo-like effect, or due to the context of participating in a meditation intervention, including expectations, shifted attention, the setting, body posture, breathing, or other processes associated with the simple awareness or belief that one is practicing meditation.
In 2015, The Journal of Neuroscience published a study whose goal was to precisely determine whether or not the neuronal mechanisms of mindfulness meditation-induced pain relief were similar to those of placebo analgesia, or if they were due to contextual influences.
The study combined different approaches, including psychophysical, physiological, and brain imaging methods, to test the hypothesis that mindfulness meditation reduces pain by activating specific neurological mechanisms, different from those of placebo analgesia. Given the impact that the context of a meditation intervention can have on pain perception, as mentioned above, the study also compared the effect of active mindfulness meditation with a sham mindfulness meditation technique – one that would lead the participants to believe that they were practicing mindfulness meditation, but that would only engage relaxation mechanisms.
As had been hypothesized, it was found that mindfulness meditation decreased pain intensity and unpleasantness beyond the analgesic effects of placebo or sham mindfulness meditation. Furthermore, effective mindfulness meditation engaged brain mechanisms that were indeed distinct from those of placebo-induced analgesia or sham mindfulness meditation.
Whereas sham mindfulness meditation-induced analgesia was associated with lower respiration rates, reflecting a relaxation response, mindfulness meditation-reduced pain ratings were independent of respiration rate and were achieved via neurological mechanisms of pain modulation. Mindfulness meditation decreased the activation of brain regions involved in processing sensory information and in the cognitive modulation of pain. This study indicated that mindfulness meditation is an active cognitive practice, whereas a placebo effect arises from a more passive cognitive state.
What was still to be understood were the details of how mindfulness meditation induces the analgesic effect, what neurochemical pathways it activates in the brain. The same research group from the aforementioned study now aimed at trying to find an answer for that. In a new study, also published in The Journal of Neuroscience, they hypothesized that, given the high concentrations of opioid receptors found in brain regions associated with the cognitive modulation of pain, and the known involvement of endogenous opioids in the cognitive inhibition of pain, maybe this system could be part of the mechanisms of mindfulness meditation-induced analgesia.
Using naloxone, a drug that blocks the effect of opioids, it was shown that the inhibition of the opioid system did not affect analgesia induced by mindfulness meditation. In the control group, on the other hand, the blockade of the opioid system induced an increase in pain perception, as expected. Although there are many other neurotransmitter systems which can account for the analgesic effect of mindfulness meditation, these results are still surprising – the opioid system is one of the main modulators of pain and the fact that it apparently has no influence on the mechanisms of mindfulness meditation-induced analgesia is intriguing.
The authors of this study speculate on some alternative explanations for this effect. They suggest that “mindfulness meditation may be a complex, cognitive process that likely engages multiple brain networks and neurochemical mechanisms to attenuate pain.”
Mind over matter
Indeed, there is mounting evidence indicating that mindfulness meditation activates brain regions associated with the contextual evaluation of pain. A reduced activity of the thalamus has also been reported; this is important because the thalamus is one of the main structures in pain processing – it receives sensory information, processes it, and then transmits it to the cortex, were it reaches consciousness. The fact that thalamic activity may be reduced due to mindfulness meditation therefore indicates that it may somehow diminish sensory processing, or that it may prevent this sensory information from reaching conscious awareness.
Although there is still a lot to be learned about its processes, what seems somewhat clear is that mindfulness meditation may be an interesting alternative approach to pain management – it’s mind over matter.
by Sara Adaes For Brain Blogger
In the 1970s, a truth was accidentally discovered about depression – one that was quickly swept aside, because its implications were too inconvenient, and too explosive. American psychiatrists had produced a book that would lay out, in detail, all the …
Today more and more people experience troubles with their sleep - insomnia, sleep apnea, lack of energy in the morning. How do you create a good night routine? How do you fight all these sleeping disorders? It might be surprising but actually a lot of …
It's not a lie when it's said that what you project is exactly what you receive. The universe is a mirror, you see, a reflection of your inner state. The whole interaction between the external Macrocosm of this universe and internal Microcosm of y…
Astrophysicist Paul Davies at Arizona State University suggests that advanced technology might not even be made of matter. That it might have no fixed size or shape; have no well-defined boundaries. Is dynamical on all scales of space and time. Or, con…