Alternative MethodsConventional Methods


March 29

Can Diet Accelerate the Development of Alzheimer’s Disease?

Earnest Chandler
Core Spirit member since Dec 24, 2020
Reading time 4 min.

The Western diet or the standard American diet has been recognized as one of the most common food diets in the world. An increasing number of studies have shown that it could be connected to an increased risk for Alzheimer’s disease.

The Western diet is generally characterized by increased levels of refined and processed foods, with elevated content of simple sugars such as sucrose and fructose, sodium, saturated fat, and red meat-derived protein, and with decreased levels of monounsaturated and polyunsaturated fatty acids, protein from plants and fiber.

This type of diet has been identified as a leading factor in the development of metabolic and obesity-related diseases such as type 2 diabetes. Four features of this diet are suggestive of increased risk for various diseases. These features are increased fat and phosphate content and decreased calcium and vitamin D levels. One well-publicized study demonstrated that the human Western diet induces tumors in the colon of normal mice.

More studies have shown that elevated mortality from diseases such as breast cancer is linked to the Western diet. This type of food intake also increases plasma levels of sex hormones while decreasing sex hormone-binding proteins and the formation of mammalian lignans and isoflavonic phytoestrogens. This, in turn, affects hormone production and degradation by decreasing the excretion of these compounds in feces and minimizing the intestinal metabolism and regulation of the enterohepatic circulation.

Another study also showed that increased acid levels in Western diet causes increased bone resorption and bone calcium loss resulting to osteoporosis and calcium nephrolithiasis.

Along with a sedentary lifestyle, obesity is characterized by chronic accumulation of excessive fat in the adipose tissue. It is widespread in both developing and developed countries and has become a leading public health concern followed by under-nutrition and infectious disease. The cardiovascular and metabolic effects of obesity have been understood for a long time; recently, however, increasing number of studies have shown that Western diet and its health implications such as obesity are also connected to the increased risk for Alzheimer’s disease.

The Western diet & Alzheimer’s disease

Alzheimer’s disease is a chronic progressive neurodegenerative disease brought about by deposition of beta-amyloid protein and neurofibrillary tangles. Characterized by declining cognitive processes such as lapses in memory and reasoning, it is the most common form of dementia and often occurs concomitantly with increasing age.

The Western diet significantly affects cognitive functions, particularly the hippocampal area, which involves areas of learning and memory functions, attributed to increased intake of simple carbohydrates and saturated fats present in Western diet. Another study has also shown that Western-style diet affects hippocampal size by decreasing its volume. This diet is also associated with disrupting blood-brain barrier integrity. Excessive food intake, strongly related to obesity, interferes with hippocampal-dependent memory inhibition which is responsible for controlling animal responses to environmental signals that imitate food, eventually driving a vicious cycle of excessive calorie intake.

Associations between Western diet consumption and Alzheimer’s disease have been established by some recent studies. One particular study which utilized a “Western diet” preparation (foodstuffs with increased amounts of animal products, fats, and low-nutrient density sugars to be consumed by mice) found out that long periods of consumption of this diet increase microglial activity in both non-Alzheimer’s and Alzheimer’s brain models. This strongly suggests increased susceptibility to Alzheimer’s disease in the presence of chronic inflammatory conditions. Due to this increased immune response in the brain, TREM2, a regulatory protein present during increased microglial activity, is also elevated. TREM2 is significantly associated with increased risk for Alzheimer’s disease and other age-linked neurodegenerative conditions. The study also showed that increased levels of beta-amyloid plaques correlates with elevated TREM2 level in mice brain.

As mentioned previously, obesity is a major risk factor in the development of type 2 diabetes, which is generally characterized by increased resistance of insulin receptors to insulin. A study has shown that insulin resistance is implicated in the development of Alzheimer’s disease. Insulin reaches the blood-brain barrier from the peripheral system and competes with beta-amyloid for the brain’s insulin degrading enzyme. This eventually causes the increased levels of beta-amyloid protein.

Another study has shown that young individuals who possess the apo-E4 allele have a seven-fold higher risk of developing Alzheimer’s disease if exposed to high-fat diet, such as a Western-style diet, in comparison to individuals who consume the same diet but don’t have this allele. The Apo-E protein is a transport protein responsible for the mobility of cholesterol in the body and one of its forms, apo-E4, is associated with the development of Alzheimer’s disease.

A number of studies have shown that the risk of age-related cognitive decline can be reduced by consumption of foods containing polyunsaturated fatty acids, monounsaturated fatty acids and fish meat. There is increasing evidence that unsaturated fatty acids have a neuroprotective effect, although no specific molecular mechanism is yet clearly identified. Nevertheless, unsaturated fatty acids help to maintain the integrity of neuronal membranes and regulate neuronal transmission. Increased consumption of polyunsaturated fatty acids such as docosahexaenoic acid (DHA) is shown to increase cognitive ability in Alzheimer’s disease model rats, at the same time inhibiting cognitive decline.

Recent scientific data clearly indicate that wrong diet can accelerate the cognitive decline and progression of Alzheimer’s disease. On the other hand, increased consumption of protein-derived plant protein, vegetable oils and fat from fish meat helps to decrease the risk of developing both early- and late-onset Alzheimer’s disease in non-genetically susceptible individuals. These new findings definitely need to be taken into account when considering the care for individuals at higher risk of neurodegenerative conditions.

by Viatcheslav Wlassoff For Brain Blogger

Comments

Leave your questions here

To write a comment you must
or
Services
Category filter
Concern filter
Type filter
Sort
 

All categories

Spiritual Healing
$220 USD
I will do spiritual transformation for you

I will do spiritual transformation. Life occurs as a series of cycles in a single human lifetime. Cycles exist in almost a spiral pattern. There is a flow and …

Wisdom Realms
Chinese Astrology
$10 USD
You are not ALONE

Do you think it’s your fault you haven’t found your partner yet? Or that you are the problem because the relationship is not working? Do you feel isolated, set…

Carmen Oana Oglan
Spiritual Healing
$55 USD
1 Hr Intuitive Nutrition Coaching Call

Dive in and discover your biggest areas of struggle and how to tap into the intuition for guidance.
We will talk about your history and your goals for your wel…

Jess Olson
Spiritual Healing
$10 USD
Praying for the Sick and Depressed

Are you sick? Are you really depressed? Do you feel that your life is worthless?
Come book a session with me and see the changes that will occur after that.
Th…

Luck Richards Omorede
5
Chakra Balancing
$10 USD
Soul To Soul Reading Session

Energetic Reading

Complete Chakra System Reading to identify energy blocks.
Techniques are provided to restore balance.

What Is An Energetic Reading?

Debo…

Deborah Lucero
Spiritual Healing
$222 USD
Healing from Trauma at a Quantum Soul Level

Are you burnt out from clinical therapy practices that require years of treatment with few results? Are you ready to release and transmute your trauma once and…

LunaRio Silver Deer
Career Coaching
$499 USD
Reset 1-0n1 Coaching and Mentoring Programme

Are you returning to work after a career break, or are you looking for a new job or career change?

This programme is for you.

I’ve developed the RESET coachi…

Carla Martins
Life Coaching
$399 USD
1-on-1 Coaching

The journey started with our discovery call, and You decided: ” I’m ready! Let’s do this!”.

We will engage in 1-on-1 coaching sessions for 90 minutes. In this…

Carla Martins
Emotional Stress Release
$800 USD
Retreat( India): Connect With Your Inner Wisdom 1st to 4th Sept

Join us for an immersive experience anchored amidst the beauty and tranquillity of Kasar Devi, Almora, India

1st Sept’22 ( Thursday) - 4th Sept 2022 ( Sunday …

Aikyam
Psychic Reading
$80 USD
I will do oracle and tarot card readings

I will do oracle & tarot card reading in any area of your life. You will get answer from the Angelic, Elemental, Faerie or Galactic realms. I will share wi…

Wisdom Realms
Natal Astrology
$15 USD
15 min reading of SOUL structure

[SOUL STRUCTURE]Each soul has own structure,and knowing it means to have unlimited access to inner energy. This readings are telling about your talents and str…

Ksenia Jdanova
Wellness Coaching
$10 USD
Ask a Question?

Supportive reflection of a current question that you would like clarity around. Using the SMART method to seek quidance in stepping onto your path of potential…

Beverly Lynn
Reiki
$150 USD
Reiki Services (distant healing session)

In this hour long distant healing session I will use long distance Reiki, crystals and essential oils to balance your Chakras. Balancing your Chakras allows en…

Erin Kirby
Tarot Reading
$10 USD
Intuitive Tarot Reading

Affordable Tarot reading to offer guidance on any given concern.

Elphie Shoppe
Telepsychology
$10 USD
Talk Therapy Sessions

Hello there: These times are dread. Do you need to talk with a safe professional about a troubling personal challenge? I am a professional listener and will li…

Eulalee Thompson
Tarot Reading
$10 USD
Tarot Reading

I offer tarot readings with a 100% accuracy rate. The tarot is meant to give you advice, to point you in the right direction or to provide you with clarity. Bu…

Zara Kalil
Angel Healing
$10 USD
Mental Health Advice & Tips

I can help you with past issues and give advice and tips on how to better your life. I can see through my third eye and receive messageson what you need to do …

Beings Of Light
Life Coaching
$10 USD
Discovery call

Are you interested in supporting your health with safe and effective holistic medicine? Not sure if you should switch diets, work with a health coach or explor…

Suzana Da Costa
Wellness Coaching
$50 USD
Mental Health and Holistic Lifestyle Coaching

Hi there! I’m Doug and I offer 1 on 1 Holistic Lifestyle and Mental Health Coaching sessions. Navtigating life with mental health issues of any sevarity is a h…

Doug Peterson
Wellness Coaching
$10 USD
Mental Health and Holistic Lifestyle Coaching Consultation

Hi there! I’m Doug and I offer 1 on 1 Holistic Lifestyle and Mental Health Coaching sessions. Navtigating life with mental health issues of any sevarity is a h…

Doug Peterson
Family Psychology
$10 USD
Psychic Reading

Expert in Love Relationship, Tarot Psychic Reading
I can give you more powerful insight of every part of your life. With the help of Crystal ball my Psychic re…

Aamir Bilal
Career Coaching
$195 USD
Holistic Lifestyle & Nutrition Coaching

ARE YOU TIRED? STRESSED OUT? STRUGGLING WITH YOUR WEIGHT? UNDER SLEPT?
LOST YOUR ZEST FOR LIFE?

If this sounds like you, then you don’t need a new diet… you n…

David Giddings
Bach flower therapy
$120 USD
Bach Flower Essence Consultation

Exploration of where you’re feeling stuck or limited in life and recommendations of Bach Flower Essences to help loosen and dissolve old patterns.

Suzana Da Costa
Cognitive-behavioral therapy
$100 USD
Subliminal therapy

In this service we will use Subliminal therapy and Sound healing as alternative to tradition cognitive behavioral therapy.

We are born with our thoughts. Do n…

Ahmed Amin Youssef