Alternative MethodsConventional Methods


May 2

Anti-cancer drug may alleviate symptoms of autism

Sylvester Dean
Core Spirit member since Dec 24, 2020
Reading time 2 min.

New study led by the State University of New York at Buffalo indicates an anti-cancer drug could have the ability to reverse social impairments related to autism.In a paper currently published in the journal Nature Neuroscience, the researchers report how low doses of romidepsin – a drug approved in the United States for treating lymphoma – “restored gene expression and reversed social deficits” in a mouse model of autism.

Autism spectrum disorder (ASD), which is a developmental condition, affects behaviour, social interaction, and communication.

Statistics which were compiled in the U.S. suggest that 1 in 68 children have ASD and it’s around four to five times more prevalent in boys than in girls.

Although it’spossible to diagnose the disorder at age two, most diagnoses of ASD aren’t confirmed before the age of 4.

The economic costsin the U.S. for kids with ASD are estimated to be in the range $11.5 billion to $60.9 billion.

Low doses ‘reversed social deficits’

Of all the challenging and catastrophic symptoms which accompany ASD, difficulty interacting with other people and forming connections is especially upsetting and there’spresently no effective therapy.

The new study is regarded as the first to demonstrate that it may be possible to relieve this key symptom of ASD by targeting a large number of genes associated with the disorder.

“We have discovered,” says senior study author Zhen Yan, a professor at the Department of Physiology and Biophysics, “a small molecule compound that shows a profound and prolonged effect on autism-like social deficits without obvious side effects .”

This, she considers, is especially important because “many currently used compounds for treating a variety of psychiatric diseases have failed to exhibit the therapeutic efficacy for this core symptom of autism.”

In their analysis, Prof. Yan and her groupdiscovered that 3 days of therapy with low doses of romidepsin “reversed social deficits” in mice using a deficient SHANK3 gene, which is a known risk factor for ASD.

The reversal in social deficits lasted for 3 weeks, from juvenile into late adolescence – thatcan be a vitalphase in mice to developing communication and social skills and is equal to several human decades.

This indicates a similar therapymay be long-lasting in humans, suggest the researchers.

Epigenetic mechanism

This new study builds on previous work with mice by Prof. Yan and group that demonstrated how loss of SHANK3 disrupts the n-methyl-D-aspartate receptor, which helpsregulate emotion and cognition. The disruption caused difficulties in communication between brain cells and contributed to ASD-related social deficits.

To quantify social deficits in the mice, the scientists put them in controlled surroundings where they could evaluate their preference for social stimuli (such as interacting with another mouse) versus preference for non-social stimuli (for instance,investigating an inanimate object).

The research showed how romidepsin was able to undo the social deficits by restoring the role of genes via an epigenetic mechanism.

Epigenetic mechanisms are genetic processes capable of switching genes on and off and changing their expression without altering their underlying DNA code. Yan states that previous studies have implied that epigenetic alterations might have a largeimpact in ASD.

One of the critical outcomes of this new study is the fact that it proves that it may be possible to target a large number of ASD-related genes with only 1 medication.

Romidepsin is a histone modifier, which is a type of compound that changes the proteins, or histones, that help arrange the DNA in the nucleus.

The medication “loosens up the densely packed chromatin,” Prof. Yan describes. The end result is to restore gene expression by making the genes accessible to the molecules whichtranslate their instructions.

With thehelp of genome-wide screening, the researchers found that romidepsin restored gene expression in the majority ofthose 200-andgeneswhich were silenced in the autism mouse model used in the research.

“The advantage of being able to adjust a set of genes identified as key autism risk factors may explain the strong and long-lasting efficacy of this therapeutic agent for autism.”

Comments

Leave your questions here

To write a comment you must
or
Services
Category filter
Concern filter
Type filter
Sort
 
All categories
Oracle Cards Reading
$22 USD
Clarity Session

Hello from Eclectic Healing & Wellness. Thank you for this oppitunity to connect with you. This private clarity sessoon we will take a deep dive to discov…

Tyisha Morris
United States of America flag icon
Spiritual Healing
$270 USD
One-On-One Healing Session

I connect with your higher self/soul to channel the messages, blockages, guidance you need to hear for all life issues. From chronic pain, anxiety, depression,…

Dawn Cady
Australia flag icon
Wellness Coaching
$10 USD
Your Missing Manual for Health & Life!

Are you constantly reading books, blogs and listening to podcasts trying to figure out what to do to be healthy?

With so much conflicting information out ther…

Pamela Malo
United States of America flag icon
Positive Psychology
$10 USD
Initial Video Consult

Explore the fit and hear how I would address your therapeutic goal

Alex Guthrie, LMFT
United States of America flag icon
Spiritual Healing
$10 USD
HEALING / Life- Coaching Session

When you aren’t sure which way to turn or who to turn to for help in making decisions, I will help you come home to yourself and forge a plan to manifest your …

Dr. Michele S. Zirkle
United States of America flag icon
Life Coaching
$50 USD
Transformative Coaching Session

You will receive a private 1:1 transformative coaching session, focused on the area(s) in your life which you are most looking to improve, expand, and/or trans…

Tyisha Morris
United States of America flag icon
Tarot Reading
$10 USD
Tarot Reading - Checking in with the universe

“What does the universe want me to know?” is a common question. During uncertain times, it may be difficult to identify a single topic to focus upon. During th…

Jessica Karels
United States of America flag icon
Personal Development Coaching
$120 USD
Spiritual Life Coach Session-Personalized Session

Personalized Sessions

Because Everyone Is Unique

Sessions are based on the area of focus requested by the client.

Each session is a LIVE Session Goals will…

Deborah Lucero
United States of America flag icon
Chakra Balancing
$60 USD
Soul To Soul Reading Session

Energetic Reading

Complete Chakra System Reading to identify energy blocks. Techniques are provided to restore balance.

What Is An Energetic Reading?

Debo…

Deborah Lucero
United States of America flag icon
Channeling
$50 USD
Healing guidance session

You prepare your questions and I channel the root cause of the issue, as easy as that!

Every session looks different. We dive deep into the root and heal it f…

Nanna
5
Sweden flag icon
Spiritual Healing
$20 USD
Compassionate energy healing

For those times when we feel we need the energetic space to let our whole being restore itself. The healing is meant to give you a sense of safety and feel lik…

Nanna
Sweden flag icon
Distance Healing
$10 USD
Reiki and Energy Healing (Distant)

Reiki and energy healing is done by distance while a client is resting and the practitioner sends healing energy to the client. Clients have found that the en…

Beverly Lynn
Canada flag icon
Spiritual Healing
$80 USD
Soul Healing and Spiritual Advice

If you need a change in your life, if you are stuck and really want to move forward, if you see unwanted repeated patterns of life events or people’s behaviour…

Yavenirie - Spiritual Witchery Practice and…
United Kingdom of Great Britain and Northern Ireland flag icon
Spiritual Healing
$10 USD
Initial consultation for Spiritual Advice or Soul Healing Journey

You can book an initial spiritual consultation with me to touch base on your struggles and ways we can work together. The session will be online for around 15 …

Yavenirie - Spiritual Witchery Practice and…
United Kingdom of Great Britain and Northern Ireland flag icon
Shamanic Healing
$10 USD
Light the Path to Your Desired Life

If you want find what is that in life that makes you happy and fulfilled you need to heal all levels of your existence- Body, Mind, and Spirit. We are all ener…

Change Naturopathy
New Zealand flag icon
Emotional Freedom Technique
$10 USD
The Power Of Emotional Healing - EFT Program

“The Power of Emotional Healing” is energy psychology education in the Emotional Freedom Technique with the perfect balance of information, instructions, video…

Dawn Cady
Australia flag icon
Art Therapy
$50 USD
Artist Teacher Workshop Or Tutoring

“Life Force” guiding our history, our body and spirits. Self portrait art, life drawing from the live model, gesture, and plein air painting. And extended cont…

Bryan Prillwitz
United States of America flag icon
Tarot Reading
$100 USD
Timeline Reading

EGYPTIAN TAROT READINGS using unique methods developed by Nelise Carbonare, a Brazilian healer with more than 40 years of experience in tarot consultations, as…

Nelise Carbonare
United States of America flag icon
Tarot Reading
$120 USD
THE SYNERGY OF THE PYRAMID

THE SYNERGY OF THE PYRAMID focuses on a specific relationship: One side for the consultant and one for their partner. (the partner does not need to be present …

Nelise Carbonare
United States of America flag icon
Tarot Reading
$10 USD
Pick one card

Many questions can be answer with just one Arcane.

Do you want to try?

Nelise Carbonare
United States of America flag icon
Personal Development Coaching
$50 USD
Spiritual Coaching - Removing Energy Blocks - Expansion

> “Who looks outside dreams. Who looks inside awakens.” Jung

Spiritual coaching is about moving you into a profound state of empowerment and involution m…

Kimla Rose (Kim Desrosiers)
United States of America flag icon
Life Coaching
$10 USD
Life Purpose and Soul Wisdom

What is your deeper truth, your deeper knowing, your MOJO, your deepest desires, those feelings that you can’t explain but that are so pure and so clear…or may…

Anna Beale
United States of America flag icon
Nutritional Therapy
$150 USD
Nutritional Therapy Consultation

Hi my name is Aria and I am the founder of Heal with Nutrition. I am a registered Nutritional Therapist and a Naturopath who has a passion on Nutrition and Hea…

Aria Alexandrou
United Kingdom of Great Britain and Northern Ireland flag icon
Tarot Reading
$10 USD
THOTH AND HERMETIC DECKS READING

With a deep knowledge of hermeticism and being introduced to the kabbalah tradition of the emanation process from the tree of life, I provide a deep insight co…

James Marchiori
Ireland flag icon

Related Articles