Alternative MethodsConventional Methods


March 29

Schizophrenia’s Strongest Genetic Link

Grace Armstrong
Core Spirit member since Dec 24, 2020
Reading time 2 min.

The discovery of a runaway gene is being touted as one of schizophrenia’s greatest breakthroughs. Researchers have discovered a gene that prunes away communication infrastructure in the brain, and when this gene prunes too much, schizophrenia can develop. This finding offers hope for detection, treatment, and possibly prevention of this largely mysterious but devastating disease.

A team of NIH-funded scientists in Massachusetts examined the genomes of 65,000 people (about 29,000 of whom had schizophrenia), 700 postmortem brains, and genetically engineered mice to examine genetic risks related to schizophrenia. The gene they discovered, called complement component 4, or C4, is one of more than 100 chromosomal sites that are already known to be associated with schizophrenia. Most of the already-identified genes are related to neurodevelopment, neuroplasticity, immunology, and neuroendocrinology.

C4 has known roles in immunity, but it was interesting to schizophrenia researchers because it is highly variable among individuals: people have different numbers of copies of the C4 gene and distinct DNA sequences that can make the gene work differently in different people. Note that this is not normally how most genes work, which made the C4 gene a puzzling subject to investigate.

The C4 protein produced by the gene supports connections between neurons in the brain (synapses). When the brain is maturing, the C4 protein prunes synapses that are no longer needed, thus optimizing the brain’s performance. In humans, most of this pruning and streamlining of the brain’s synapses occurs during the late teenage years or early adulthood. Not so coincidentally, this is the same time as the onset of most cases of schizophrenia.

The gene is expressed primarily in two main forms: C4A and C4B. The more C4A that is present in the brain, the greater the risk for schizophrenia. Essentially, the more C4, the more pruning, and the more lost synapses.

Schizophrenia is characterized by hallucinations, delusions, dysfunctional thought processes, and agitated body movements. Current treatments, including antipsychotic medications, only treat the symptoms of the disease and not the underlying cause. To date, genetic and environmental factors have been suspected of increasing the risk of schizophrenia, including psychosocial stress, cannabis use, and living in urban areas.

Schizophrenia affects about 1% of the US population and 21 million people worldwide. It is believed to be almost entirely heritable, but the specific genetic activities related to its development and the precise pathogenesis of this complex disease have been largely unknown until now. The discovery of the relationship between C4 and brain maturation changes the focus of schizophrenia research, potentially leading to early detection, novel treatments to counteract excessive C4 activity, and even prevention in those at risk of the disease.

by Jennifer Gibson For Brain Blogger

Comments

Leave your questions here

To write a comment you must
or
Services
Category filter
Concern filter
Type filter
Sort
 

All categories

Nutritional Therapy
$10 USD
Discovery Call

Whether you’re looking for feeling in control of your life and food habits, making peace with your body and falling in love with it, dropping stress burden, de…

Nora
Life Coaching
$10 USD
Searching for Life Purpose

Feel lost? Feel as if there is more out there for you? Feel that you are just living day to day without a passion? Spend an hour and speak to me and lets se…

Kelly Valentine
Spiritual Healing
$220 USD
I will do spiritual transformation for you

Life occurs as a series of cycles in a single human lifetime. Cycles exist in almost a spiral pattern. There is a flow and everything is connected so you can b…

Wisdom Realms
Spiritual Healing
$10 USD
Praying for the Sick and Depressed

Are you sick? Are you really depressed? Do you feel that your life is worthless?
Come book a session with me and see the changes that will occur after that.
Th…

Luck Richards Omorede
5
Spiritual Healing
$55 USD
1 Hour Intuitive Nutrition Coaching Call

Dive in and discover your biggest areas of struggle and how to tap into the intuition for guidance.
We will talk about your history and your goals for your wel…

Jess Olson
NLP
$100 USD
Weightloss Course

If your goal is to lose weight once and for all, I will support you closely,
to understand the resources they need to become the person you want.

You probably…

rossella tocco
Chinese Astrology
$10 USD
You are not ALONE

Do you think it’s your fault you haven’t found your partner yet? Or that you are the problem because the relationship is not working? Do you feel isolated, set…

Carmen Oana Oglan
Chakra Balancing
$10 USD
Soul To Soul Reading Session

Energetic Reading

Complete Chakra System Reading to identify energy blocks.
Techniques are provided to restore balance.

What Is An Energetic Reading?

Debo…

Deborah Lucero
Spiritual Healing
$222 USD
Healing from Trauma at a Quantum Soul Level

Are you burnt out from clinical therapy practices that require years of treatment with few results? Are you ready to release and transmute your trauma once and…

LunaRio Silver Deer
Career Coaching
$499 USD
Reset 1-0n1 Coaching and Mentoring Programme

Are you returning to work after a career break, or are you looking for a new job or career change?

This programme is for you.

I’ve developed the RESET coachi…

Carla Martins
Life Coaching
$399 USD
1-on-1 Coaching

The journey started with our discovery call, and You decided: ” I’m ready! Let’s do this!”.

We will engage in 1-on-1 coaching sessions for 90 minutes. In this…

Carla Martins
Emotional Stress Release
$800 USD
Retreat( India): Connect With Your Inner Wisdom 1st to 4th Sept

Join us for an immersive experience anchored amidst the beauty and tranquillity of Kasar Devi, Almora, India

1st Sept’22 ( Thursday) - 4th Sept 2022 ( Sunday …

Aikyam
Psychic Reading
$80 USD
I will do oracle and tarot card readings

I will do oracle & tarot card reading in any area of your life. You will get answer from the Angelic, Elemental, Faerie or Galactic realms. I will share wi…

Wisdom Realms
Natal Astrology
$15 USD
15 min reading of SOUL structure

[SOUL STRUCTURE]Each soul has own structure,and knowing it means to have unlimited access to inner energy. This readings are telling about your talents and str…

Ksenia Jdanova
Wellness Coaching
$10 USD
Ask a Question?

Supportive reflection of a current question that you would like clarity around. Using the SMART method to seek quidance in stepping onto your path of potential…

Beverly Lynn
Reiki
$150 USD
Reiki Services (distant healing session)

In this hour long distant healing session I will use long distance Reiki, crystals and essential oils to balance your Chakras. Balancing your Chakras allows en…

Erin Kirby
Tarot Reading
$10 USD
Intuitive Tarot Reading

Affordable Tarot reading to offer guidance on any given concern.

Elphie Shoppe
Telepsychology
$10 USD
Talk Therapy Sessions

Hello there: These times are dread. Do you need to talk with a safe professional about a troubling personal challenge? I am a professional listener and will li…

Eulalee Thompson
Tarot Reading
$10 USD
Tarot Reading

I offer tarot readings with a 100% accuracy rate. The tarot is meant to give you advice, to point you in the right direction or to provide you with clarity. Bu…

Zara Kalil
Angel Healing
$10 USD
Mental Health Advice & Tips

I can help you with past issues and give advice and tips on how to better your life. I can see through my third eye and receive messageson what you need to do …

Beings Of Light
Life Coaching
$10 USD
Discovery call

Are you interested in supporting your health with safe and effective holistic medicine? Not sure if you should switch diets, work with a health coach or explor…

Suzana Da Costa
Wellness Coaching
$50 USD
Mental Health and Holistic Lifestyle Coaching

Hi there! I’m Doug and I offer 1 on 1 Holistic Lifestyle and Mental Health Coaching sessions. Navtigating life with mental health issues of any sevarity is a h…

Doug Peterson
Wellness Coaching
$10 USD
Mental Health and Holistic Lifestyle Coaching Consultation

Hi there! I’m Doug and I offer 1 on 1 Holistic Lifestyle and Mental Health Coaching sessions. Navtigating life with mental health issues of any sevarity is a h…

Doug Peterson
Family Psychology
$10 USD
Psychic Reading

Expert in Love Relationship, Tarot Psychic Reading
I can give you more powerful insight of every part of your life. With the help of Crystal ball my Psychic re…

Aamir Bilal

Related Articles