March 29

Age Reversal Pill: Scientists Unveil a Giant Leap for Anti-Aging Treatments

Maria Carter
Core Spirit member since Dec 24, 2020
Reading time 2 minutes

Researchers have made a discovery that could lead to a revolutionary drug that actually reverses ageing, improves DNA repair and could even help NASA get its astronauts to Mars.

In a paper published in Science today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA.

Their experiments in mice suggest a treatment is possible for DNA damage from ageing and radiation. It is so promising it has attracted the attention of NASA, which believes the treatment can help its Mars mission.

While our cells have an innate capability to repair DNA damage — which happens every time we go out into the sun, for example — their ability to do this declines as we age.

The scientists identified that the metabolite NAD+, which is naturally present in every cell of our body, has a key role as a regulator in protein-to-protein interactions that control DNA repair.

Treating mice with a NAD+ precursor, or “booster,” called NMN improved their cells’ ability to repair DNA damage caused by radiation exposure or old age.

“The cells of the old mice were indistinguishable from the young mice, after just one week of treatment,” said lead author Professor David Sinclair of UNSW School of Medical Sciences and Harvard Medical School Boston.

Human trials of NMN therapy will begin within six months.

“This is the closest we are to a safe and effective anti-ageing drug that’s perhaps only three to five years away from being on the market if the trials go well,” says Sinclair, who maintains a lab at UNSW in Sydney.

What it means for astronauts, childhood cancer survivors, and the rest of us

The work has excited NASA, which is considering the challenge of keeping its astronauts healthy during a four-year mission to Mars.

Even on short missions, astronauts experience accelerated ageing from cosmic radiation, suffering from muscle weakness, memory loss and other symptoms when they return. On a trip to Mars, the situation would be far worse: five per cent of the astronauts’ cells would die and their chances of cancer would approach 100 per cent.

Professor Sinclair and his UNSW colleague Dr Lindsay Wu were winners in NASA’s iTech competition in December last year.

“We came in with a solution for a biological problem and it won the competition out of 300 entries,” Dr Wu says.

Cosmic radiation is not only an issue for astronauts. We’re all exposed to it aboard aircraft, with a London-Singapore-Melbourne flight roughly equivalent in radiation to a chest x-ray.

In theory, the same treatment could mitigate any effects of DNA damage for frequent flyers. The other group that could benefit from this work is survivors of childhood cancers.

Dr Wu says 96 per cent of childhood cancer survivors suffer a chronic illness by age 45, including cardiovascular disease, Type 2 diabetes, Alzheimer’s disease, and cancers unrelated to the original cancer.

“All of this adds up to the fact they have accelerated ageing, which is devastating,” he says.

“It would be great to do something about that, and we believe we can with this molecule.”

An anti-ageing pill could be on the horizon

For the past four years, Professor Sinclair and Dr Wu have been working on making NMN into a drug substance with their companies MetroBiotech NSW and MetroBiotech International.

The human trials will begin this year at Brigham and Women’s Hospital, in Boston.

The findings on NAD+ and NMN add momentum to the exciting work the UNSW Laboratory for Ageing Research has done over the past four years.

They’ve been looking at the interplay of a number of proteins and molecules and their roles in the ageing process.

They had already established that NAD+ could be useful for treating various diseases of ageing, female infertility and also treating side effects of chemotherapy.

In 2003, Professor Sinclair made a link between the anti-ageing enzyme SIRT1 and resveratrol, a naturally occurring molecule found in tiny quantities in red wine.

“While resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity,” he says.

Story Source:

Materials provided by University of New South Wales. Note: Content may be edited for style and length.

Comments

Leave your questions here

To write a comment you must
or
Services
Category filter
Concern filter
Type filter
Sort
 
All categories
Art Therapy
$50 USD
Artist Teacher Workshop Or Tutoring

“Life Force” guiding our history, our body and spirits. Self portrait art, life drawing from the live model, gesture, and plein air painting. And extended cont…

Bryan Prillwitz
United States of America flag icon
Tarot Reading
$100 USD
Timeline Reading

EGYPTIAN TAROT READINGS using unique methods developed by Nelise Carbonare, a Brazilian healer with more than 40 years of experience in tarot consultations, as…

Nelise Carbonare
United States of America flag icon
Tarot Reading
$120 USD
THE SYNERGY OF THE PYRAMID

THE SYNERGY OF THE PYRAMID focuses on a specific relationship: One side for the consultant and one for their partner. (the partner does not need to be present …

Nelise Carbonare
United States of America flag icon
Tarot Reading
$10 USD
Pick one card

Many questions can be answer with just one Arcane.

Do you want to try?

Nelise Carbonare
United States of America flag icon
Personal Development Coaching
$50 USD
Spiritual Coaching - Removing Energy Blocks - Expansion

> “Who looks outside dreams. Who looks inside awakens.” Jung

Spiritual coaching is about moving you into a profound state of empowerment and involution m…

Kimla Rose (Kim Desrosiers)
United States of America flag icon
Life Coaching
$10 USD
Life Purpose and Soul Wisdom

What is your deeper truth, your deeper knowing, your MOJO, your deepest desires, those feelings that you can’t explain but that are so pure and so clear…or may…

Anna Beale
United States of America flag icon
Wellness Coaching
$10 USD
Your Missing Manual for Health & Life!

Are you constantly reading books, blogs and listening to podcasts trying to figure out what to do to be healthy?

With so much conflicting information out ther…

Pamela Malo
United States of America flag icon
Nutritional Therapy
$150 USD
Nutritional Therapy Consultation

Hi my name is Aria and I am the founder of Heal with Nutrition. I am a registered Nutritional Therapist and a Naturopath who has a passion on Nutrition and Hea…

Aria Alexandrou
United Kingdom of Great Britain and Northern Ireland flag icon
Tarot Reading
$10 USD
THOTH AND HERMETIC DECKS READING

With a deep knowledge of hermeticism and being introduced to the kabbalah tradition of the emanation process from the tree of life, I provide a deep insight co…

James Marchiori
Ireland flag icon
Personal Development Coaching
$55 USD
The Bridge to Your Desired Life

This is were you get real help with your struggles and life challenges. As life gets harder to cope with, we tend to look for external ways to get through. And…

Mina Mikhail
United States of America flag icon
Naturopathy
$10 USD
Intake Consult

short introduction consult to Integrative Medicine

Femke Neervoort
Netherlands flag icon
Career Coaching
$300 USD
Reset Coaching and Mentoring Programme

12 weeks of bi-weekly 90 minutes 1:1 Coaching and Mentoring. Total cost USD1800 (6x90minutes career coaching and mentoring session)

Are you returning to work …

Carla Martins
United Kingdom of Great Britain and Northern Ireland flag icon
Personal Development Coaching
$120 USD
Spiritual Life Coach Session-Personalized Session

Personalized Sessions

Because Everyone Is Unique

Client-centered sessions based on the area of focus requested by the client.

Each session is a LIVE Sessio…

Deborah Lucero
United States of America flag icon
Reiki
$55 USD
Guidance, Inspiration & Healing

This type of session is a favorite among many of my clients, as it is often times one of the smoothest way to address a challenge to reach a happier and health…

Mina Mikhail
United States of America flag icon
Mediumism
$10 USD
Psychic Readings

I specialize in love, past present future, future, past life, general, tarot, dream interpretation, specific, social, and career readings! Book today for clari…

Holly
United States of America flag icon
Life Coaching
$399 USD
1-on-1 Coaching

The journey started with our discovery call, and You decided: ” I’m ready! Let’s do this!”.

We will engage in 1-on-1 coaching sessions for 90 minutes. In this…

Carla Martins
United Kingdom of Great Britain and Northern Ireland flag icon
Ascension
$88 USD
Ascension Mentor Support

In this session, we come together with similar to a healing session but face to face.

We talk about what issues you are facing at the moment and we delve deep…

Claire C.
Australia flag icon
Spiritual Healing
$177 USD
Energy Healing

I am honored to assist you with intuitive channeled energy healings that support and nurture you on a physical level as well soul and energetic level, each ses…

Claire C.
Australia flag icon
Reiki
$375 USD
Usui Reiki 1st Degree Course

FIRST DEGREE COURSE - The ultimate Reiki course.

Have you ever wondered if you can heal? Have you felt a burning desire to help others? Then you’ve come to th…

Step Into Your Light - Christina Moore
United Kingdom of Great Britain and Northern Ireland flag icon
Life Coaching
$10 USD
Hand Analysis - Startup Session

What does a hand analysis do for me? ​

You will understand yourself and your life purpose. ​You will understand the roots of your triggers and reactionary be…

Brent Bruning, Master Hand Analyst
Switzerland flag icon
Shamanism
$10 USD
Sample Akashic Records Reading for Your Burning Issue

I connect to your Akashic Records and listen to what your guides want to bring to your conscoius attention at this time. Perhaps, it is an insight into why you…

Olga Aydınoğlu
Turkey flag icon
Shamanic Healing
$300 USD
Shamanic Healing Art

What is Shamanic Healing Art?

It is a physical artwork (usually a pastel drawing) I make for you based on the outcome of our online session. This artwork will…

Olga Aydınoğlu
Turkey flag icon
Shamanic Healing
$70 USD
Heal to say "No"

A limits and boundaries shamanic healing session to help you heal relevant wounds and traumas from this and/or other lifetimes, let go of false beliefs, judgem…

Olga Aydınoğlu
Turkey flag icon
Shamanic Healing
$70 USD
Writer's Block Shamanic Healing Session

Before the Session

I do my pre-meditation to find out the main reasons for your writer’s block. (This happens psychically, where I generally just need your na…

Olga Aydınoğlu
5
Turkey flag icon